논문검색
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Title In vivo Sarcoma 180 과 mouse Lewis Lung Carcinoma 에 대한 유산균의 항암효과 ( In vivo Antitumor Effects of Lactic Acid Bacteria on Sarcoma 180 and Mouse Lewis Lung Carcinoma )
Publicationinfo 1991 Jan; 023(02): 188-197.
Key_word Ascites tumor, Sarcoma 1SO, Antitumor effect, Mean survival day, Tumor inhibition rate, Lewis lung carcinoma
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Abstract To evaluate the antitumor effect of lactic acid bacteria, seven lactic starter strains including Lactobacillus acidophilus CH 5, L. bulgaricus HY 2601, L casei YIT 9018, L. plantarum KFCC 35472, Leuconostoc mesenteroides KFCC 11324, Streptococcus thermophilus HY 2502 and Bifidobacterium bifidum 12 were used. All were heat-treated (100C for 30 min.) and lyophilized, Ascites tumors were induced by sarcoms 180 (1 x 10' cells/mouse) in ICR mice. Seven lactic acid bacteria were administer- ed intraperitoneally (100 pg/mouse) and the antitumor effect were measured by the increase of body weights and mean survival days. L. casei YIT 9018 group was more effective than any other group. Mean survival days of L. casei YIT 9018 group were longer than 43.3 days, while the control group was only 26.9 days. Solid tumors were induced by sarcoma 180 inoculation (2 x 10(6) cells/mouse) in the right groin of ICR mice. Lactic acid bacteria were administered intralesionally (100 pg/mouse). After 21 days, the tumors were picked out and weighed. L. casei YIT 9018 group (tumor weight; 0.14 g) was the most effective and the tumor inhibition rate was 87.8% in comparision with control group (tumor weight; 1.15g). Another type of solid tumors were induced by mouse Lewis lung carcinoma (2 x10(6) cells/mouse) at the right groin of C57BL/6 mice. In case of solid tumor induced by these types of tumor cells, L. casei YIT 9018 group (tumor weight; 0.41g) was the most effective and the tumor inhibition rate was 77.8% in comparision with control group (tumor weight; 1.85g).
저 자 김형용(Hyung Yong Kim),배형석(Hyeong Suk Bae),백영진(Young Jin Baek)