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Title   위선암에서 CD44 Standrd , CD44 Variant 6 의 발현과 림프절 전이와의 연관성 ( Expression of CD44 Standard , Variant 6 and Relationship to the Lymph Node Metastasis in Gastric Adenocarcinoma )
Publicationinfo   2000 Jan; 032(04): 665-674.
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Abstract   Purpose: The transmembrane glycoprotein CD44 exists in a variety of isoforms generated by alternative splicing of the pre-mRNA. We studied the role of CD44-standard (CD44s) and CD44-variant6 (CD44v6) in gastric adenocarcinoma. Materials and Methods: Immunohistochemical staining was performed in 101 patients with gastric adenocarcinoma who underwent radical gastrectomy at KGCC, Seoul Paik Hospital. The relationship of CD44s, CD44v6 expressions to the clinicopathologic parameters, p53 and Ki-67 were evaluated. Results: CD44s and CD44-v6 expressions were found in 56.4% and 48.5%, respectively. CD44s expression was significantly correlated with lymph node metastasis, lymphatic invasion, and Borrmann type. CD44v6 expression was significantly correlated with sex, lymph node metastasis, lymphatic invasion, and perineural invasion and had a tendency toward p53 expression. In intestinal type adenocarcinoma, CD44s expression had correlations with lymph node metastasis and CD44v6 had correlations with lymph node metastasis, lymphatic invasion. However, in diffuse type adenocarcinoma, CD44s and CD44v6 expressions had correlations with only Borrmann type. In multivariate analysis, lymph node metastasis was the most significant risk factor for CD44s and CD44v6 expressions in total cases and intestinal type adenocarcinoma. Conclusion: These data suggest that expression of CD44 v6 may play an important role in the regulation of lymph node metastasis in intestinal type adenocarcinoma of stomach.
저 자   이주호(Joo Ho Lee),유항종(Hang Jong Yu),서병조(Byung Jo Suh),주미(Mee Ju),이혜경(Hae Kyung Lee),김진복(Jin Pok Kim)