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Title   진행성 위암에 대한 5 - Fluorouracil ( 5 - FU ) 5 일 지속주입 및 Cisplatin 복합화학요법 : 5 - FU 혈증농도 측정의 의의 ( Chemotherapy with Five - Day Continuous Infusion of 5 - Fluorouracil ( 5 - FU ) Plus Cisplatin for Advanced Gastric Cancer : Significance of 5 - FU Concentration Mon
Publicationinfo   2000 Jan; 032(03): 516-524.
Key_word   Stomach neoplasm , Continuous infusion , 5 - FU , Pharmacokinetics
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Abstract   Purpose: To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adenocarcinoma and to elucidate the relationship between the pharmacokinetic (PK) parameters and therapeutic outcome. Materials and Methods: Patients with previously untreated advanced stomach cancer were treated with FP chemotherapy. Plasma concentrations of 5-FU were measured using gas chromatography method for 5 days. Correlation of PK parameters of 5-FU with clinical outcome after FP chemotherapy was studied. Results: Response rate of FP chemotherapy was 46% (95% C.I.: 30-62%). There was a wide range of difference in the concentration and area under the curve (AUC) of 5-FU from patient to patient. We could find significant differences in AUC of 5-FU between the responders and the non-responders (p<0.05). Conclusion: We could confirm that FP chemotherapy was effective and tolerable for the treatment of advanced stomach cancer. The monitoring of plasma 5-FU concentration after chemotherapy and the adjustment of subsequent 5-FU dose seems to be necessary to improve the treatment outcome of FP chemotherapy.
저 자   박연희(Yeon Hee Park),김봉석(Bong Seog Kim),류백렬(Baek Yeol Ryoo),김태유(Tae You Kim),임영혁(Young Hyuck Im),신호상(Ho Sang Shin),강윤구(Yoon Koo Kang)