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Title   위선암종의 진행과 금속의존성 기질분해효소의 상관성 ( Interrelation between the Progression of Gastric Adenocarcinoma and the Matrix Metalloproteinases )
Publicationinfo   2000 Jan; 032(03): 497-506.
Key_word   Stomach neoplasm , Matrix metalloproteinase
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Abstract   Purpose: An essential element in tumor invasion and metastasis in the degradation of extracellular matrix is matrix metalloproteinases (MMPs). But little is known about the role of them in the gastric adenocarcinoma. The purpose of this study was to determine whether human gastric adenocar-cinoma expressed MMPs and whether MMPs were concerned in tumor stage and histologic subtypes. Materials and Methods: The authors performed the retroactive analysis in 38 cases of early gastric carcinoma (EGC) and 61 cases of advanced gastric carcinoma (AGC), including 38 cases of diffuse type and 61 cases of intestinal type, using immunohistochemical staining for MMP-2, -3 and -9. Results: MMP-2, -3 and -9 were localized to neoplastic cells in 93% (92/99), 32% (32/99) and 76% (76/99), respectively. MMP-2 and -9 were found mainly in tumors of intestinal type and less frequently in those of diffuse type. There were positive correlation between the presence of MMP-2 and -9 and lymph node metastasis. There was positive correlation between MMP-2 expression and tumor stage. Conclusion: The authors demonstrated a statistically significant expression of tumoral MMP-2, -3 and -9 in gastric adenocarcinoma and their correlation with tumor progression. This study also suggests that the presence of MMP-2 and/or -9 is a useful indicator for poor prognosis.
저 자   임성철(Sung Chul Lim),이미자(Mi Ja Lee),박찬국(Chan Kook Park)