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Title   장막 침범 위암 환자에서 수술 후 복강내 Cisplatin 투입의 치료 효과 ( 후향적 연구 ) ( Therapeutic Effect of the Intraperitoneal Cisplatin Installation ( IPCI ) in Advanced Gastric Carcinoma with Serosa Invasion )
Publicationinfo   2000 Jan; 032(06): 1015-1022.
Key_word   Stomach neoplasm , Intraperitoneal cisplatin installation , Peritoneal recurrence
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Abstract   Purpose: We performed retrospective study to evaluate the preventive effect of intraperitoneal cisplatin installation (IPCI) on peritoneal recurrence after curative resection of advanced gastric cancer. Materials and Methods: The effect of IPCI was evaluated in 297 advanced gastric carcinoma patients from January 1993 to December 1996. In IPCI group, 100 mg/body of cisplatin in one liter of saline was installed in peritoneal cavity before wound closure in operating room and drained out 2 hours later. Postoperative adjuvant chemotherapy with combination of 5-FU and cisplain was performed. 155 cases were treated by IPCI. Median follow-up period was 26 months. Results: Out of 139 (46.8%) recurred cases, peritoneal, local and distant recurrences developed in 65 (37.8%) cases, 66 (38.4%) cases and 41 (23.8%) cases respectively. In univariated analysis for survival and recurrence, IPCI, T stage and N stage were significant prognostic factors. As regards to peritoneal recurrence, IPCI and T stage were significant factors. In multivariated survival analysis, as regards to recurrence, IPCI, T stage and N stage were significant prognostic factors. As regards to peritoneal recurrence, IPCI was the only significant independent prognostic factor. Conclusion: We concluded that IPCI can effectively prevent peritoneal recurrence and overall recurrence and it shows marginal survival benefit in advanced gastric cancer patients with serosa invasion.
저 자   김병식(Byung Sik Kim),박건춘(Keun Chun Park),김행수(Haeng Su Kim),곽진호(Jin Ho Kwak),김용호(Yong Ho Kim),이창환(Chang Hwan Lee),육정환(Jung Hwan Yook),오성태(Seung Tae Oh)