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Title   위선암의 진행과 간세포성장인자와의 관련 ( Significant of Hepatocyte Growth Factor Level with Progression of Gastric Adenocarcinoma )
Publicationinfo   1997 Jan; 029(03): 367-374.
Key_word   Hepatocyte Growth Factor(HGF), Gastric adenocarcinoma, Differentiation, Progression
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Abstract   Purpose: Hepatocyte growth factor(HGF) is a modulator of epithelial cell proliferation and motility. In this study, we measured the level of HGF in sera and tumor extracts of gastric adenocarcinoma using an enzyme-linked immunoassay and evaluated its association with tumor progression. Materials and Methods: The level of HGF in the sera of seventy-five patients with gastric adenocarcinoma and in the tumor extracts of forty-two tumors were examined in this study. The level of HGF was determined by an Immunis HGF EIA kit(Institute of Imrnunology). Results: The mean level of HGF in the sera of patients was 0.26+-0.19 ng/ml, which was significantly higher than in those of healthy controls(0.14+-0.07 ng/ml, p<0.05); the levels of HGF in the sera of patients increased according to the progression of the stage of cancer(p < 0.05). The mean level of HGF in tumor extracts was 8.22+- 9.27 ug/g protein, which was significantly higher than in those of healthy controls(1.95+-1.45 ug/g protein, p <0.05); the levels of HGF in the tumor extracts were correlated significantly with the progression of the tumor stage(p < 0.05). The mean level of HGF in the tumors of diffuse type was 11.28+-11.74 ug/g protein, which was significantly higher than in those of intestinal type(5.16+-4.31 ug/g protein, p<0.05). Conclusion: HGF may play an important role in the progression and differentiation of gastric adenocarcinoma.
저 자   한상욱(Sang Uk Han),이재호(Jae Ho Lee),김욱환(Wook Hwan Kim),왕희정(Hee Jung Wang),조용관(Yong Kwan Cho),김명욱(Myung Wook Kim)