논문검색
Author Mee Soo Chang, Woo Ho Kim
Place of duty Departments of Pathology, 1Seoul National University College of Medicine, 2Seoul National University Boramae Hospital, Seoul, Korea.
Title Epstein-Barr Virus in Human Malignancy: A Special Reference to Epstein-Barr Virus associated Gastric Carcinoma
Publicationinfo Cancer Res Treat. 2005 Oct; 037(05): 257-267.
Key_word Human herpes virus 4,Epstein-Barr virus (EBV),Oncogenic virus,Stomach neoplasms,Lymphoma,EBV-targeted treatment
Full-Text
Abstract Epstein-Bar virus (EBV), a human herpesvirus, establishes a life-long persistent infection in 90~95% of human adult population worldwide. EBV is the etiologic agent of infectious mononucleosis, and EBV is associated with a variety of human malignancy including lymphoma and gastric carcinoma. Recently, EBV has been classified as group 1 carcinogen by the WHO International Agency for Research on Cancer. Evidence is presented which suggests that failures of the EBV-specific immunity may play a role in the pathogenesis of EBV-associated malignancy. At present, the precise mechanisms by which EBV transforms B lymphocytes have been disclosed. Encouragingly, they have had enough success so far to keep them enthusiastic about novel therapeutic trial in the field of EBV-associated lymphoma. However, information on EBV-associated gastric carcinoma is still at dawn. This article reviews EBV biology, immunological response of EBV infection, unique oncogenic property of EBV, peculiarity of EBV-associated gastric carcinoma, and lastly, EBV-targeted therapy and vaccination. (Cancer Res Treat. 2005;37:257-267)