논문검색
Author Hee Yeon Seo, M.D.1, Eui Bae Kim, M.D.1, Jee Won Kim, M.D.1, Bong Kyoung Shin, M.D.2, Seok Jin Kim, M.D., Ph.D.3, Byung Soo Kim, M.D.1
Place of duty 1Division of Oncology and Hematology, Department of Internal Medicine, 2Department of Pathology, Korea University College of Medicine, 3Division of Hematology/Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Title Complete Remission in a Patient with Human Herpes Virus-8 Negative Multicentric Castleman Disease Using CHOP Chemotherapy
Publicationinfo Cancer Res Treat 2009 Jun; 041(02): 104-107.
Key_word Chemotherapy, Human herpes virus 8, Multicentric Castleman disease
Full-Text
Abstract Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months' duration. The complete blood count revealed an elevated leukocyte count (15.1103/L) and a decreased hemoglobin level of 10.0 g/dL. The C-reactive protein level was elevated at 276.5 mg/L. Thoracic computed tomography (CT) scans revealed bilateral axillary lymph-adenopathy. There was no evidence of HHV-8, human immunodeficiency virus (HIV), or Mycobacteriuminfection. Histologic evaluation of a lymph node biopsy from the left axilla yielded a diagnosis of MCD. Cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) were administered for a total of 4 cycles. The patient's fever and lymphadenopathy resolved after the course of chemotherapy. She has been in complete remission for 24months at this writing. As previously reported, this case report suggests that MCD can develop without viral infection. CHOP chemotherapy may be an effective treatment option for newly diagnosed MCD patients.
출판정보 대한암학회지 2009 Jun; 041(02): 104-107.