논문검색
Author Jung Yeon Kim, M.D.1Byung-Noe Bae, M.D.2Kyoung Soo Kim, Ph.D.3Eunah Shin, M.D.1Kyeongmee Park, M.D.1
Place of duty Department of 1Pathology and 2Surgery, Inje University Sanggye PaikHospital, 3Kyung Hee University East-WestNeomedical Center Bone & Joint Research Center, Seoul, Korea
Title Osteopontin, CD44, and NFՊBExpression in GastricAdenocarcinoma
Publicationinfo Cancer Res Treat 2009 Mar; 041(01): 29-35.
Key_word Stomach, Adenocarcinoma, Osteopontin, CD44, NFՊB
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Abstract PurposeOsteopontin (OPN) binds to CD44 and nuclear factor-ՊB (NFՊB) and OPN mediatestumorigenesis, invasion and metastasis, but the interrelationships between OPN, CD44and NFՊB are not fully understood, and especially in gastric carcinogenesis. We examinedthe expressions of OPN, CD44, and NFՊB in untreated gastric adenocarcinomas. Materials and MethodsThe materials from 211 cases of gastric adenocarcinoma were immunostained for OPN,CD44 and NFՊB by using a tissue microarray. The OPN mRNA expression was measuredin 10 cases by performing real-time RT-PCR.ResultsThe expression of OPN, CD44 and NFՊB was noted in 61.7%, 11.4% and 26.6% of theadenocarcinoma tissues, respectively. No significant correlation was detected among theexpressions of these proteins. The OPN protein expression was negatively correlated withangioinvasion (p<0.05) and patient survival (p<0.05), whereas the CD44 and NFՊB proteinexpressions were not correlated with any of the clinicopathological factors we examined.The depth of invasion, lymph node status and perineural invasions were prognostic factorsbased on the Cox analysis. The OPN mRNA expression showed no significant differencebetween the adenocarcinoma and the paired normal mucosa on real-time RT-PCR.ConclusionOPN may have a currently undetermined role in gastric carcinogenesis, and CD44 and NFՊB may have minor roles in gastric adenocarcinoma
출판정보 대한암학회지 2009 Mar; 041(01): 29-35.