논문검색
Author Se Hyun Kim, M.D.1, Hyun Cheol Chung, M.D., Ph.D.1,2, Jaeheon Jeong, M.D.1, Ji Hoon Kim, M.D.4, Sun Young Rha, M.D., Ph.D.1,2, Joong Bae Ahn, M.D., Ph.D.1,2, Nam Hoon Cho, M.D., Ph.D.3, and Hei-Cheul Jeung, M.D., Ph.D.1,2
Place of duty 1Department of Internal Medicine, 2Cancer Metastasis Research Center, Yonsei Cancer Center, 3Department of Pathology, Yonsei University College of Medicine, 4Department of Internal Medicine, Hongik Hospital, Seoul, Korea
Title A Locally Advanced Breast Cancer with Difficult Differential Diagnosis of Carcinosarcoma and Atypical Medullary Carcinoma, which had Poor Response to Adriamycin- and Taxane-based Neoadjuvant Chemotherapy: A Case Report
Publicationinfo Cancer Res Treat 2007 Sep; 039(03): 134-137.
Key_word Atypical medullary carcinoma, Carcinosarcoma, Metaplastic breast cancer, Neoadjuvant chemotherapy
Full-Text
Abstract Atypical medullary carcinomas and carcinosarcoma have unique histopathological features. Here we present a case with a breast malignancy that had pathological characteristics of both. A 54-year old patient with a malignant breast mass received 6 cycles of adriamycin-based chemotherapy, followed by 3 cycles of paclitaxel monotherapy, and had a poor clinical response to treatment. A modified radical mastectomy was performed. The pathological diagnosis was complicated by an inability to distinguish between atypical medullary carcinoma and carcinosarcoma. The findings included a tumor that was well-circumscribed, high grade and a syncytial growth pattern as well as biphasic sarcomatous and carcinomatous characteristics. In conclusion, atypical medullary carcinoma and carcinosarcoma of the breast have entirely different prognoses and should be managed differently. Both should be treated by surgical resection, and additional therapy should be considered based on the cancer with the poorer prognosis. (Cancer Res Treat. 2007;39:134- 137)
출판정보 대한암학회지 2007 Sep; 039(03): 134-137.