논문검색
Author Yoon Seok Choi, M.D.1, Seok Jin Kim, M.D., Ph.D.1, Dae Sik Kim, M.D.1, Seh Jong Park, M.D.1, Yong Park, M.D.1, Hye Jin Shin, M.S.2, Kwang-Yoon Jung, M.D., Ph.D.3, Seung-Kuk Baek, M.D., Ph.D.3, Bong Kyung Shin, M.D., Ph.D.4, Jung Woo Choi, M.D.4, Byung Soo Kim, M.D., Ph.D.1, Sang Won Shin, M.D., Ph.D.1, Yeul Hong Kim, M.D., Ph.D.1 and Jun Suk Kim, M.D., Ph.D.1
Place of duty 1Department of Internal Medicine, Korea University Medical Center, 2Graduate School of Korea University, 3Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Medical Center, 4Department of Pathology, Korea University Medical Center, Seoul, Korea
Title Glucose Transporter-1 Expression in Squamous Cell Carcinoma of the Tongue
Publicationinfo Cancer Res Treat 2007 Sep; 039(03): 109-115.
Key_word Tumor hypoxia, Glucose transporter-1, Squamous cell carcinoma, Tongue
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Abstract Purpose: Tumor cells are known to express hypoxia-related proteins such as glucose transporter-1 (Glut-1). These hypoxia-induced changes may allow tumor cells to survive under sustained hypoxic microenvironments, and the surviving tumor cell under hypoxia may develop a more aggressive phenotype and so result in a poor prognosis. Materials and Methods: The Glut-1 expression was analyzed by immunohistochemistry, and its association with the prognosis was assessed in 60 patients with squamous cell carcinoma of the tongue. Results: The Glut-1 expression was diffuse with a membranous pattern, and the median percentage of Glut-1 positive tumor cells was 60% (range: 0.0∼90.0%). A high Glut-1 expression (the percentage of positive tumor cells ≥ the median value, 60%) was associated with the location of primary lesion, lymph node metastasis status and disease stage (p＜0.05). The expression of Glut-1 was correlated with the Ki-67 expression (r=0.406, p=0.001). Microvessel density, as represented by CD31 staining, was also correlated with the Glut-1 expression although its significance is weak (r=0.267, p=0.039). On the univariate analysis, the group with a high Glut-1 expression showed poorer overall survival than the group with a low Glut-1 expression (p＜0.05). However, the Glut-1 expression failed to show any independent prognostic significance on the multivariate analysis. Conclusion: The expression of Glut-1 may be useful for predicting the prognosis and determining the treatment strategy for the management of squamous cell carcinoma of the tongue. (Cancer Res Treat. 2007;39:109-115)
출판정보 대한암학회지 2007 Sep; 039(03): 109-115.