논문검색
Author Sangwon Kim, M.D.1, Mison Chun, M.D.1, Heejung Wang, M.D.3, Sungwon Cho, M.D.2, Young-Taek Oh, M.D.1, Seung-Hee Kang, M.D.1 and Juno Yang, O.M.D.1
Place of duty 1Departments of Radiation Oncology, 2Surgery and 3Internal Medicine, Ajou University School of Medicine, Suwon, Korea
Title Bone Metastasis from Primary Hepatocellular Carcinoma: Characteristics of Soft Tissue Formation
Publicationinfo Cancer Res Treat 2007 Sep; 039(03): 104-108.
Key_word Bone metastasis, hepatocellular carcinoma, soft tissue formation, radiation therapy
Full-Text
Abstract Purpose: To assess the characteristics of bone metastasis from hepatocellular carcinoma and the radiation field arrangement based on imaging studies. Materials and Methods: Fifty-three patients (84 lesions) with bone metastasis from a primary hepatocellular carcinoma completed palliative radiation therapy. All patients underwent one of following imaging studies prior to the initiation of radiation therapy: a bone scan, computed tomography or magnetic resonance imaging. The median radiation dose was 30 Gy (7∼40 Gy). We evaluated retrospectively the presence of soft tissue formation and the adjustment of the radiation field based on the imaging studies. Results: Soft tissue formation at the site of bony disease was identified from either a CT/MRI scan (41 lesions) or from a symptomatic palpable mass (5 lesions). The adjustment of the radiation field size based on a bone scan was necessary for 31 of 41 soft tissue forming lesions (75.6%), after a review of the CT/MRI scan. The median survival from the initial indication of a hepatoma diagnosis was 8 months (2 to 71 months), with a 2-year survival rate of 38.6%. The median survival from the detection of a bone metastasis was 5 months (1 to 38 months) and the 1-year overall survival rate was 8.7%. Conclusion: It was again identified that bone metastasis from a primary hepatocellular carcinoma is accompanied by soft tissue formation. From this finding, an adjustment of the radiation field size based on imaging studies is required. It is advisable to obtain a CT or MRI scan of suspected bone metastasis for better tumor volume coverage prior to the initiation of radiation therapy. (Cancer Res Treat. 2007; 39:104-108)
출판정보 대한암학회지 2007 Sep; 039(03): 104-108.